The WhatsApp Business API is Meta's programmatic interface for businesses to send and receive WhatsApp messages at scale, distinct from the consumer WhatsApp Business app. Tools like ManyChat, Sleekflow and Meta's own Business Agent build their automation on top of it.
The WhatsApp Business API lets a business connect its own systems, or a third-party platform, to WhatsApp messaging beyond what the free WhatsApp Business app supports: multiple team members handling one number, automated replies, catalog-based messaging and programmatic sends triggered by other software.
Access usually runs through a Business Solution Provider such as ManyChat or Sleekflow, which host the number and charge separately for hosting and per-conversation messaging fees on top of their own subscription. Meta Business Agent uses the same underlying API, but bundles the hosting and messaging cost into Meta One's business tiers instead of billing them separately.
This is the layer every WhatsApp automation tool actually sits on top of, which is why comparing ManyChat, Sleekflow and Meta Business Agent is really a comparison of who manages the WhatsApp Business API connection on your behalf and what they charge for doing it. A business evaluating any WhatsApp automation tool is, underneath the marketing language, evaluating a different way to access the same underlying interface.